Clinical implications of elevated serum interleukin-6 in IgG4-related disease
Identifieur interne : 000497 ( 2020/Analysis ); précédent : 000496; suivant : 000498Clinical implications of elevated serum interleukin-6 in IgG4-related disease
Auteurs : Satoshi Tsukuda [Japon] ; Tsukasa Ikeura [Japon] ; Takashi Ito [Japon] ; Koh Nakamaru [Japon] ; Masataka Masuda [Japon] ; Yuichi Hori [Japon] ; Manami Ikemune [Japon] ; Masato Yanagawa [Japon] ; Toshihiro Tanaka [Japon] ; Takashi Tomiyama [Japon] ; Takashi Yamaguchi [Japon] ; Yugo Ando [Japon] ; Kazushige Uchida [Japon] ; Toshiro Fukui [Japon] ; Akiyoshi Nishio [Japon] ; Rika Terasawa [Japon] ; Noboru Tanigawa [Japon] ; Kazuichi Okazaki [Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2020.
Abstract
Some patients with IgG4-related disease (IgG4-RD) exhibit elevated serum interleukin (IL)-6 with excessive inflammatory reactions or with repeating relapse. To date few reports pertaining to clinical implications of elevated serum IL-6 in IgG4-RD patients have been published. The aims of the current retrospective study were to investigate the clinical implications of elevated serum IL-6 in IgG4-RD patients, and to examine whether IL-6 can predict the activity and/or relapse of the disease.
We examined the clinical picture at the onset of 43 patients who were diagnosed with IgG4-RD in our hospital and were able to measure serum IL-6 before steroid treatment.
The median level of serum IL-6 was 2.2 pg/mL. There was a significant correlation between IL-6 and C-reactive protein (CRP) level (r = 0.397,
Serum IL-6 level at the onset of IgG4-RD may be significantly correlated with clinical inflammatory parameters and it may also be associated with involvement of the bile duct, liver, and spleen.
Url:
DOI: 10.1371/journal.pone.0227479
PubMed: 31951598
PubMed Central: 6968836
Affiliations:
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Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi</wicri:regionArea><wicri:noRegion>Kochi</wicri:noRegion></affiliation></author><author><name sortKey="Fukui, Toshiro" sort="Fukui, Toshiro" uniqKey="Fukui T" first="Toshiro" last="Fukui">Toshiro Fukui</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Nishio, Akiyoshi" sort="Nishio, Akiyoshi" uniqKey="Nishio A" first="Akiyoshi" 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Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tanigawa, Noboru" sort="Tanigawa, Noboru" uniqKey="Tanigawa N" first="Noboru" last="Tanigawa">Noboru Tanigawa</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Radiology, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Okazaki, Kazuichi" sort="Okazaki, Kazuichi" uniqKey="Okazaki K" first="Kazuichi" last="Okazaki">Kazuichi Okazaki</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country 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Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Ikeura, Tsukasa" sort="Ikeura, Tsukasa" uniqKey="Ikeura T" first="Tsukasa" last="Ikeura">Tsukasa Ikeura</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Ito, Takashi" sort="Ito, Takashi" uniqKey="Ito T" first="Takashi" last="Ito">Takashi Ito</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Nakamaru, Koh" sort="Nakamaru, Koh" uniqKey="Nakamaru K" first="Koh" last="Nakamaru">Koh Nakamaru</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Masuda, Masataka" sort="Masuda, Masataka" uniqKey="Masuda M" first="Masataka" last="Masuda">Masataka Masuda</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Hori, Yuichi" sort="Hori, Yuichi" uniqKey="Hori Y" first="Yuichi" last="Hori">Yuichi Hori</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Ikemune, Manami" sort="Ikemune, Manami" uniqKey="Ikemune M" first="Manami" last="Ikemune">Manami Ikemune</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Yanagawa, Masato" sort="Yanagawa, Masato" uniqKey="Yanagawa M" first="Masato" last="Yanagawa">Masato Yanagawa</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Toshihiro" sort="Tanaka, Toshihiro" uniqKey="Tanaka T" first="Toshihiro" last="Tanaka">Toshihiro Tanaka</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tomiyama, Takashi" sort="Tomiyama, Takashi" uniqKey="Tomiyama T" first="Takashi" last="Tomiyama">Takashi Tomiyama</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Yamaguchi, Takashi" sort="Yamaguchi, Takashi" uniqKey="Yamaguchi T" first="Takashi" last="Yamaguchi">Takashi Yamaguchi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Ando, Yugo" sort="Ando, Yugo" uniqKey="Ando Y" first="Yugo" last="Ando">Yugo Ando</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Uchida, Kazushige" sort="Uchida, Kazushige" uniqKey="Uchida K" first="Kazushige" last="Uchida">Kazushige Uchida</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi</wicri:regionArea><wicri:noRegion>Kochi</wicri:noRegion></affiliation></author><author><name sortKey="Fukui, Toshiro" sort="Fukui, Toshiro" uniqKey="Fukui T" first="Toshiro" last="Fukui">Toshiro Fukui</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Nishio, Akiyoshi" sort="Nishio, Akiyoshi" uniqKey="Nishio A" first="Akiyoshi" last="Nishio">Akiyoshi Nishio</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Terasawa, Rika" sort="Terasawa, Rika" uniqKey="Terasawa R" first="Rika" last="Terasawa">Rika Terasawa</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Radiology, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Tanigawa, Noboru" sort="Tanigawa, Noboru" uniqKey="Tanigawa N" first="Noboru" last="Tanigawa">Noboru Tanigawa</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Radiology, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Okazaki, Kazuichi" sort="Okazaki, Kazuichi" uniqKey="Okazaki K" first="Kazuichi" last="Okazaki">Kazuichi Okazaki</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Introduction</title><p>Some patients with IgG4-related disease (IgG4-RD) exhibit elevated serum interleukin (IL)-6 with excessive inflammatory reactions or with repeating relapse. To date few reports pertaining to clinical implications of elevated serum IL-6 in IgG4-RD patients have been published. The aims of the current retrospective study were to investigate the clinical implications of elevated serum IL-6 in IgG4-RD patients, and to examine whether IL-6 can predict the activity and/or relapse of the disease.</p></sec><sec id="sec002"><title>Materials and methods</title><p>We examined the clinical picture at the onset of 43 patients who were diagnosed with IgG4-RD in our hospital and were able to measure serum IL-6 before steroid treatment.</p></sec><sec id="sec003"><title>Results</title><p>The median level of serum IL-6 was 2.2 pg/mL. There was a significant correlation between IL-6 and C-reactive protein (CRP) level (r = 0.397, <italic>p</italic> = 0.008), hemoglobin level (r = -0.390, <italic>p</italic> = 0.010) and albumin level (r = -0.556, <italic>p</italic> < 0.001). When 43 patients were divided into two groups by using a cut-off IL-6 of 4 pg/mL, the high IL-6 group showed higher age, lower albumin, higher CRP and higher aspartate aminotransferase (AST) (age <italic>p</italic> = 0.014, albumin <italic>p</italic> = 0.006, CRP <italic>p</italic> <0.001, AST <italic>p</italic> = 0.009). Hepatic swelling and splenomegaly were significantly more prevalent in the high IL-6 group than it was in the low IL-6 group (liver <italic>p</italic> < 0.001, spleen <italic>p</italic> = 0.020). Biliary tract involvement tended to admit more in the high IL-6 group (<italic>p</italic> = 0.060).</p></sec><sec id="sec004"><title>Conclusion</title><p>Serum IL-6 level at the onset of IgG4-RD may be significantly correlated with clinical inflammatory parameters and it may also be associated with involvement of the bile duct, liver, and spleen.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Okazaki, K" uniqKey="Okazaki K">K Okazaki</name></author><author><name sortKey="Uchida, K" uniqKey="Uchida K">K Uchida</name></author><author><name sortKey="Ikeura, T" uniqKey="Ikeura T">T Ikeura</name></author><author><name sortKey="Takaoka, M" uniqKey="Takaoka M">M Takaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Umehara, H" uniqKey="Umehara H">H Umehara</name></author><author><name sortKey="Okazaki, K" uniqKey="Okazaki K">K Okazaki</name></author><author><name sortKey="Masaki, Y" 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uniqKey="Yasuoka H">H Yasuoka</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Tsukuda, Satoshi" sort="Tsukuda, Satoshi" uniqKey="Tsukuda S" first="Satoshi" last="Tsukuda">Satoshi Tsukuda</name></noRegion><name sortKey="Ando, Yugo" sort="Ando, Yugo" uniqKey="Ando Y" first="Yugo" last="Ando">Yugo Ando</name><name sortKey="Fukui, Toshiro" sort="Fukui, Toshiro" uniqKey="Fukui T" first="Toshiro" last="Fukui">Toshiro Fukui</name><name sortKey="Hori, Yuichi" sort="Hori, Yuichi" uniqKey="Hori Y" first="Yuichi" last="Hori">Yuichi Hori</name><name sortKey="Ikemune, Manami" sort="Ikemune, Manami" uniqKey="Ikemune M" first="Manami" last="Ikemune">Manami Ikemune</name><name sortKey="Ikeura, Tsukasa" sort="Ikeura, Tsukasa" uniqKey="Ikeura T" first="Tsukasa" last="Ikeura">Tsukasa Ikeura</name><name sortKey="Ito, Takashi" sort="Ito, Takashi" uniqKey="Ito T" first="Takashi" last="Ito">Takashi Ito</name><name sortKey="Masuda, Masataka" sort="Masuda, Masataka" uniqKey="Masuda M" first="Masataka" last="Masuda">Masataka Masuda</name><name sortKey="Nakamaru, Koh" sort="Nakamaru, Koh" uniqKey="Nakamaru K" first="Koh" last="Nakamaru">Koh Nakamaru</name><name sortKey="Nishio, Akiyoshi" sort="Nishio, Akiyoshi" uniqKey="Nishio A" first="Akiyoshi" last="Nishio">Akiyoshi Nishio</name><name sortKey="Okazaki, Kazuichi" sort="Okazaki, Kazuichi" uniqKey="Okazaki K" first="Kazuichi" last="Okazaki">Kazuichi Okazaki</name><name sortKey="Tanaka, Toshihiro" sort="Tanaka, Toshihiro" uniqKey="Tanaka T" first="Toshihiro" last="Tanaka">Toshihiro Tanaka</name><name sortKey="Tanigawa, Noboru" sort="Tanigawa, Noboru" uniqKey="Tanigawa N" first="Noboru" last="Tanigawa">Noboru Tanigawa</name><name sortKey="Terasawa, Rika" sort="Terasawa, Rika" uniqKey="Terasawa R" first="Rika" last="Terasawa">Rika Terasawa</name><name sortKey="Tomiyama, Takashi" sort="Tomiyama, Takashi" uniqKey="Tomiyama T" first="Takashi" last="Tomiyama">Takashi Tomiyama</name><name sortKey="Uchida, Kazushige" sort="Uchida, Kazushige" uniqKey="Uchida K" first="Kazushige" last="Uchida">Kazushige Uchida</name><name sortKey="Yamaguchi, Takashi" sort="Yamaguchi, Takashi" uniqKey="Yamaguchi T" first="Takashi" last="Yamaguchi">Takashi Yamaguchi</name><name sortKey="Yanagawa, Masato" sort="Yanagawa, Masato" uniqKey="Yanagawa M" first="Masato" last="Yanagawa">Masato Yanagawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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